The specific aims of this project were: 1) to determine if the implementation of an initial screen assessment screening would increase the number of MRSA SSTIs identified within the first 24 hours of incarceration, 2) to identify possible risk factors for acquiring a MRSA infection among data based articles published between 1999 and 2010, and 3) to identify the number of inmates that received MRSA prevention education at the time of screening. Participants consisted of male and female inmates greater than 18 years of age in a South Carolina detention center. A retrospective-descriptive chart review was conducted to determine if an initial MRSA skin assessment-screening better identified inmates with soft-skin tissue infections, as opposed to screening inmates up to 14 days after incarceration. Variables under investigation included sociodemographic variables (e.g., race, age), presence of a soft-skin tissue infection, and a history of a soft-skin tissue infection, recent hospitalization, and antibiotic use within the last 6 months, HIV, diabetes mellitus, and homelessness. Objectives of the study were to identify SSTIs as well as medical and sociodemographic risk factors that increase the risk for acquiring a MRSA soft-skin tissue infection. This project demonstrates that screening inmates on admission increases the number of MRSA infections identified at the time of incarceration. The prevention of MRSA infections is emerging as a topic for nursing research, reflecting public health attention on the topic. Increased investigative efforts are needed in the areas of MRSA prevention and education.