The common cold is one of the most common reasons for patients to see a health care provider, and is the third leading diagnosis during ambulatory visits. Patients have difficulty selecting over-the-counter cold medications. Research shows written information on medication with verbal instruction gives patients the responsibility of self-care. A written resource benefitted patients to select appropriate over-the-counter cold medication. The purpose of this project was to improve patient knowledge of over-the-counter medication. Increased selection of appropriate over-the-counter cold medication will; therefore, decrease the use of inappropriate over-the-counter cold medication. This project focused on patients at a TakeCare Health clinic, a retail clinic located in the central United States. Patients with common cold symptoms answered questions regarding their selection of over-the-counter medications. Only patients inappropriately selecting over-the-counter cold medication were included in the project. A written informational intervention was given to the patients and discussed. A follow up telephone survey determined if appropriate selection was made on over-the-counter cold medication. The survey was conducted three to five days after the clinic visit. Participants (n=30) participated in receiving an informational handout with verbal instructions on over-the-counter cold medications and completed a follow-up telephone survey. Increasing the responsibility of self-care was determined by 100% of participants referring to the informational handout after the clinical visit and 100% of the participants stated they would keep the handout to refer to in the future with common cold symptoms. There was a 90% accuracy of selecting the appropriate over-the-counter cold medication when an informational handout was given to the participants with verbal instruction. These findings provide evidence that written information is beneficial to patients to help learn the skills and accept the responsibility of self-care.