Healthcare cost is a rapidly growing problem. Inappropriate antimicrobial use is a significant contributing factor through increased pharmaceutical cost, increased length of stay (LOS), and antibiotic administration related adverse events. It has been projected that as many as 40% of patients who were initially treated with intravenous (IV) antibiotics could have been transitioned to oral (PO) antibiotics in 2-3 days (Scheinfeld, 2010). By implementing an evidence-based protocol for converting IV antimicrobials with high IV versus PO bioavailability to the PO formulation, facilities have shown a measurable decrease in cost, some decrease in LOS, and some decrease in catheter-related adverse events. It is anticipated that providers, pharmacists, and nursing staff will express increased levels of satisfaction with the utilization of this protocol as well. Although barriers occurred preventing the implementation and evaluation of this protocol as the Capstone Project, the protocol was ultimately implemented. Barriers faced during this Capstone Project are analyzed and hopefully will assist others in avoiding and overcoming similar barriers in the future.