Depression is a chronic illness that places an enormous burden on the health care system and society as a whole. College students experiencing depression are at risk for both adverse health and academic outcomes which can significantly impact their future economic and social well being. Research indicates that a coordinated, comprehensive plan for depression management can improve outcomes for individuals experiencing depression. Because of the adverse outcomes associated with depression, an evidence-based depression management plan should be made a high priority in the university health center. The purpose of this DNP capstone project was to implement an evidence-based plan for depression management in a university health center. The MacArthur Foundation Depression Management Tool Kit, a care guide, and a follow-up process were implemented with primary care providers in a university health center. This initiative provided a framework for the delivery of comprehensive evidence-based depression management for students. Provider utilization of the tool kit, care guide, and follow-up tracking system were evaluated 10 weeks after project implementation. Additionally, the impact of the project on student follow-up for depression management was evaluated by comparing project follow-up data to follow-up data obtained prior to project implementation.